Application of clinical indicators in evaluating vestibular compensation efficacy in benign recurrent vestibular vertigo patients with short-term personalized vestibular rehabilitation.

BACKGROUND: Short-term personalized vestibular rehabilitation (ST-PVR) can establish stable vestibular compensation. However, there is a lack of a clear definition for clinical indicators that can dynamically reflect the progress of vestibular rehabilitation (VR). OBJECTIVE: To explore the clinical indicators suitable for evaluating the effectiveness of ST-PVR in treating benign recurrent vertigo (BRV). METHODS: In total, 50 patients diagnosed with BRV were enrolled. All patients received the ST-PVR treatment program. At 2 and 4 weeks after rehabilitation, subjective scales, including the visual analogue scale (VAS), dizziness handicap inventory scale (DHI), activities-specific balance confidence scale (ABC) and generalized anxiety disorder (GAD-7) were assessed. Objective vestibular function tests were performed. VR grading was determined. RESULTS: At 2 weeks after rehabilitation, significant enhancements were observed in VAS, DHI, ABC, GAD-7, UW, vHIT results, and VR grading scores (p < 0.05). The sensory organization test (SOT) results demonstrated statistically significant improvements at 2 weeks and 4 weeks after rehabilitation (p < 0.05). CONCLUSION AND SIGNIFICANCE: Both subjective scales and partial examination results in objective assessment can serve as indicators to dynamically monitor the compensatory process of vestibular function in patients with BRV. The VR efficacy grading score, which incorporates the above indicators, allows for quantification of the changes that occur during the vestibular rehabilitation process.

Explosion wave and crack field of an eccentric decoupled charge.

To investigate the characteristics of the explosion damage from an eccentric decoupled charge, the rock-breaking mechanism of an eccentric decoupled charge is revealed from the perspectives of the explosion wave field and crack field through theoretical and experimental analyses. The ratio of the maximum to minimum pressure on an eccentric decoupled hole wall increases exponentially with an increase in the decoupling coefficient, but it does not change with a change in the explosive density or explosive detonation velocity. The explosive energy on the eccentric charge side has a certain accumulation effect, the velocity of the reflected shock wave at the blasthole wall is greater than that of the incident shock wave, and the incident velocity of the explosion wave on the eccentric side is greater than that on the non-eccentric side. The expansion range of the explosion gas is significantly better than that on the non-eccentric side, indicating that the eccentric decoupled charge can strengthen the action of the explosion gas product on the eccentric side. In addition, the overpressure of the explosion wave on the eccentric side is greater than that on the non-eccentric side. The fractal dimension and damage degree of the explosion crack on the eccentric side are larger than those on the non-eccentric side. The explosion cracks can be divided into intensive, transition, and sparse areas, and the fractal dimension and damage degree decrease successively in the three areas. The explosion cracks formed on the non-eccentric side outside the range of three times the blasthole diameter concentrate in the sparse area, and the destructive effect of the explosion on the non-eccentric side medium is effectively reduced.

Effect of Systemic Application of 5-Hydroxytryptamine on Hypoglossal Nerve Discharge in Anesthetized Rats.

The aim of this study is to investigate whether systemic 5-hydroxytryptamine (5-HT) can promote long-lasting form of respiratory plasticity in vivo via 5-HT2AR-activated protein kinase C (PKC) mechanism. The frequency and peak amplitude of hypoglossal nerve discharges in anesthetized rats were compared before and after intravenous injections of different treatments, including saline, 5-HT, ketanserin tartrate, or staurosporine. The administration of 5-HT at a systemic bolus imposed an initial ephemeral inhibition subsequently followed by striking facilitation, which demonstrates a biphasic manner of hypoglossal nerve output in anesthetized adult rats. The facilitatory stage conformed to the reinforced hypoglossal activity that lasted for more than 60 min after drug administration. The 5-HT evoked biphasic manner of hypoglossal output and hypoglossal nerve activity LTF (hLTF) were 5-HT2A receptor-dependent and coupled to PKC activation. The initial inhibition of hypoglossal activity was associated with nodose ganglion, and the subsequent facilitation was associated with carotid body. The reactive oxygen species (ROS) formation was triggered in the systemic 5-HT2-dependent hLTF model in vivo. The expressions of immunofluorescent histochemistry provide morphological evidence of a 5-HT/5-HT2A receptor coupled to PKC mechanism. In conclusion, systemic 5-HT challenge contributes to long-lasting form of respiratory plasticity and to elicit hLTF or elevated hLTF in animals, which with decreased or even with inhibited peripheral inhibitory activations. The effect of systemic 5-HT was regulated by a 5-HT2AR-activated PKC mechanism.

Identification of severe fever with thrombocytopenia syndrome virus in ticks collected from patients.

The cases of two patients (a husband and wife) with thrombocytopenia syndrome (SFTS) are reported herein. Both patients had a history of recent tick bite and displayed typical clinical SFTS symptoms including fever, thrombocytopenia, and leukopenia. The diagnosis was laboratory-confirmed by the provincial Center for Disease Control and Prevention (CDC). The husband died while the wife survived. SFTS virus was eventually identified in ticks collected from the couple.